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Monthly Cell challenges

Every month, we share a cell challenge on social media. Learn more about our cases and their diagnosis!
Lymphocytes CellaVision Monthly Cell Challenge January 2026

Monthly Cell Challenge #01/ 2026: Spot the Difference

A 72-year-old male was referred to the hematology clinic due to progressive fatigue, unintentional weight loss, night sweats, and abdominal discomfort over the past several months.  

Monthly Cell Challenges from 2025

A 3-year-old boy was referred for hematologic evaluation due to unusual granulation observed in his white blood cells on a recent peripheral smear.

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Lymphocytes from the CellaVision Monthly cell challenge December 2025

A 13-year-old spayed female dog was presented for her routine annual health check. She appeared bright, alert, and in good general condition, with no signs of fever or lymphadenopathy.

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Lymphocytes from the CellaVision Monthly cell challenge November 2025

A 67-year-old gentleman went to his general practitioner for a check-up because of weight-loss and swollen lymph nodes. The patient also had a history of rash and hair loss.

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Abnormal lymphocytes Monthly Cell Challenge May 2025

A 68-year-old woman presented to the emergency department with complaints of back and hip pain, progressive weight loss, shortness of breath, fever, generalized weakness, nausea, and vomiting.

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NRBC Monthly Cell Challenge September 2025

A 7-year-old spayed female German Shepard came to the vet clinic after the owners noticed a few days of reduced general condition, fatigue, loss of appetite and labored breathing. The veterinarian ordered a CBC and differential. 

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Neutrophils from the monthly cell challenge August 2025

A 54-year-old female came to the ER with fever, nausea, vomiting and diarrhea, abdominal pain, shortness of breath, weakness, and loss of weight and appetite. She also had severe sinus congestion, edema, and enlarged spleen and liver.

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Neutrophils from the monthly cell challenge July 2025

A 58-year-old male presented to the emergency room with fever, weakness, abdominal pain, enlarged lymph nodes, enlarged spleen, shortness of breath and loss of appetite.

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Blasts from the monthly cell challenge June 2025

A 78-year-old man went for his yearly check-up at his general physician. Lately, he had some trouble with tiredness and recurrent infections but had not thought much about it.  

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Lymphocytes from the CellaVision Monthly cell challenge May 2025

A 2-year-old girl went to a pediatrician with her parents because of unexplained fever, fatigue, weakness, weight loss and shortness of breath. 

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Monoblasts from the CellaVision Monthly Cell Challenge April 2025

A 6-year-old dog, adopted from a shelter in Spain, arrives with its owner to their local veterinarian in Germany because of fatigue, weight-loss, and coughing.

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Full Field view CellaVision

A 9-year-old female presented to the pediatric emergency room with fever, weakness, bone pain, enlarged lymph nodes, shortness of breath and loss of appetite.

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Cells from the Monthly cell challenge February 2025

A 9-year-old female presented to the pediatric emergency room with fever, weakness, bone pain, enlarged lymph nodes, shortness of breath and loss of appetite.

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Monthly cell challenge 2025 01 - cell classes

Monthly Cell Challenges from 2024

74-year-old male presented to the emergency department with weakness, shortness of breath, abdominal pain, and unexplained bruising.

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acute leukemia from cell challenge november 2024

A 47-year-old male with cough, fever, unexpected weight loss, pain, and generalized lymphadenopathy was seen by his primary caregiver. Routine labs were ordered.

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Most cells exhibited nuclear shape irregularities / Monthly Cell Challenge #2

4-year-old girl with fever, stuffy nose, inflamed tonsils with white spots, and swollen lymph nodes was seen by her pediatrician. A Monospot test was negative. 

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Monthly cell challenge 1 - Reactive lymphocyte