CellaVision Global Test 2025:2– Lyme Disease – Borrelia Spirochete case
Case Description
A 28-year-old woman presented with a 10-day history of flu-like symptoms, including high-grade fevers, fatigue, joint pain, and swelling of the right knee. She reported a recent sports-related injury to the same knee. The patient is subsequently referred to the emergency department for urgent assessment and diagnostic investigation.
Laboratory Findings
|
Test |
Result |
Reference Interval (female) |
Unit |
|
WBC |
11.7 |
4.0-11.0 |
x109/L |
|
HB |
11.2 |
12.1-15.1 |
g/dL |
|
RBC |
3.8 |
4.2-5.4 |
x1012/L |
|
PLT |
129 |
150-450 |
x109/L |
Analyzer
CellaVision DC-1, MGG stain
Sample of cells classified in the Global Test 2025:2
RBC Overview
Case conclusion
An adult female presented with fever, fatigue, joint pain, and right knee swelling. Blood smear showed neutrophilia, lymphopenia, thrombocytopenia with giant platelets, and spirochetes. Findings suggest a systemic spirochetal infection. Given monoarticular arthritis and presence of spirochetes, Lyme arthritis is likely. Absence of early Lyme signs (e.g., rash) does not exclude late-stage disease. Serologic testing is recommended to confirm diagnosis and guide treatment.
Global Test 2025:2 Results Webinar
Questions discussed during the webinar include:
• Examine peripheral smear findings, including spirochete visualization and compare participant and examiner results
• Review diagnostic approach to systemic spirochetal infections with hematologic involvement
• Correlate clinical symptoms and laboratory results in distinguishing infectious from autoimmune causes of arthritis
• Emphasize the importance of integrating clinical history, including recent trauma, in differential diagnosis formation