Global test 2024:2 - Mantle Cell Lymphoma
Case Description
A 77-year-old man with night sweats, fever, unexplained weight loss, fatigue, pruritis, lymphadenopathy, and splenomegaly.
Laboratory Findings
|
Test |
Result |
Reference Interval |
Unit |
|---|---|---|---|
|
WBC |
38.5 |
4.5-11.5 |
x109/L
|
|
HGB |
7.9 |
14-17.5 |
g/dL |
|
MCV |
101.2 |
80-100 |
fL |
|
PLT |
36 |
150-450 |
x109/L |
|
LDH |
elevated |
|
|
|
β2-microglobulin |
elevated |
|
|
Sample of cells classified in the Global Test 2024:2
RBC Overview
Case Conclusion
CBC and Differential: Leukocytosis, anemia, and thrombocytopenia. Increased absolute lymphocyte count due to a population of abnormal lymphocytes, most with mature chromatin, irregularly shaped nuclei, and high N:C ratios suggestive of a mature lymphoid neoplasm. Additional diagnostic tests identified mantle cell lymphoma; neutrophilic left shift, Pelger-Huet neutrophils, NRBCs at various stages of maturation and NRBCs with dysplastic features. Numerous smudge cells possibly originating from abnormal lymphocytes.
RBC morphology: anisocytosis, polychromasia, numerous echinocytes, and RBCs containing distinct pappenheimer bodies.
Global Test 2024:2 Results Webinar
Webinar objectives
- Compare participant and examiner results
- Discuss clinical and laboratory findings and diagnostic criteria of leukemic mantle cell lymphoma
- Compare morphology of abnormal lymphocytes with morphological subtypes in mantle cell lymphoma
- Correlate clinical and laboratory findings with pathological mechanisms
- Discuss the possibility of concurrent myelodysplastic neoplasm (MDS) in this patient
- Review RBC morphology and potential explanations for echinocytes and pappenheimer bodies