Interactive Hematopoiesis Flowchart

Hematopoiesis is a process of blood cell production and maturation in the bone marrow. 

The process begins with the pluripotent stem cell. The stem cell is capable of proliferating, differentiating, and replicating. The differentiation into a myeloid or lymphoid stem cell takes place in response to growth factors (cytokines). 

The lymphoid stem cell differentiates into a pre-B or pre-T stem cell. The myeloid stem cell produces an intermediate stem cell, which differentiates into erythroid, megakaryocytic, myeloid, monocytic, eosinophilic, or basophilic lineage. 

The most immature stem cells can not be morphologically identified.

Note, that this flowchart illustrates only normal hematopoietic pathways and blood cell findings. Pathologic or abnormal variations are not included here. For further exploration of atypical cell morphology please refer to our Blood Cell Encyclopedia.