CellaVision Global Test 2024:4 – B Cell Lymphoma
Case Description
A 70-year-old female diagnosed with non-Hodgkin lymphoma presented with fever, night sweats, weight loss, lymphadenopathy, and hepatosplenomegaly.
Laboratory Findings
|
Test |
Result |
Reference Interval |
Unit |
|
WBC |
7.4 |
4.5-11.5 |
x109/L
|
|
HGB |
13.3 |
14-17.5 |
mg/dL |
|
MCV |
90.0 |
80-100 |
fL |
|
PLT |
180 |
150-450 |
x109/L |
Sample of cells classified in the Global Test 2024:4
RBC Overview
Case Conclusion
The patient’s hemoglobin, WBC count, and platelet count were normal; however, the WBC differential revealed approximately 10% abnormal lymphocytes. These cells exhibited condensed chromatin, high nuclear-to-cytoplasmic (N:C) ratios, irregular nuclear contours, and deep, narrow nuclear clefts. Flow cytometry confirmed the presence of a population of clonal B cells.
Global Test 2024:4 Results Webinar
Questions discussed during the webinar include:
- Compare participant and examiner results
- Discuss the morphological characteristics of abnormal/malignant lymphocytes
- Differentiate chronic lymphocytic leukemia (CLL), follicular lymphoma, mantle cell lymphoma, and other B-cell neoplasms based on morphology, immunophenotype, and genetic features
- Discuss leukemic involvement in non-Hodgkin lymphoma
- Review the International Council for Standardization in Hematology (ICSH) guidelines for classifying reactive and malignant lymphocytes, and smudge cells.