Variant Lymphocyte

  • 15-30 microns
  • Round, oval, indented, notched, folded, cleaved or lobulated nucleus
  • None to multiple nucleoles
  • Plentiful grey to blue cytoplasm
  • Cytoplasm may be darker in the periphery and lighter near the nucleus
 

Toxic Granulation

  • Found in neutrophils
  • Large irregular violet-purple granules
  • Increase in staining density and numbers of granules
  • Granules not evenly distributed
 

Sezary Cell

  • 8 -20 microns
  • Round or oval but can also be irregular
  • Prominently folded, convoluted and often cerebriform nuclei Pale, blue to gray cytoplasm is scant and may contain small vacuoles 
  • The finding is associated with disease states such as Sézary syndrome, eczema, psoriasis, mycosis fungoides, HIV infection and other viral illnesses
 

Platelet Satellitism

  • Found at neutrophils and monocytes
  • Cell surface is surrounded with 4 or more platelets
  • Morphology and function of the leukocyte and the platelet is normal
  • In vitro phenomenon in EDTA anticoagulated blood
 

Nucleated Red Blood Cell

  • 8-10 microns
  • Small, round or oval nucleus with coarser chromatin strands, pyknotic
  • Pink cytoplasm
  • Nucleos decreases in size as the cell ages
  • No nucleoles
 

Hypersegmented Neutrophil

  • Increased size and lobulation
  • 6 or more lobes
  • The condition is often indicative of reduced DNA synthesis
  • Associated with vitamin B12 deficiency, folate deficiency, anti-metabolite therapy or alcoholism
 

Döhle Bodies

  • 1-2 microns Light blue or blue-gray oval structure
  • Usually found at the periphery of the neutrophil
  • Consist of ribosomes and endoplasmic reticulum
  • Found in bacterial infections and in a benign inherited condition known as May-Heggling Anomaly
 

Blast Cell

  • 10-20 microns
  • Large round to oval nucleus
  • Fine evenly stained chromatin structure
  • 1-5 nucleoles
  • Relatively small amount of blue cytoplasm with clear zone closest to the nucleus
  • No granules
 

Auer Rods

  • 0.2-0.5 microns
  • Azurphilic round or rod shaped cytoplasmic inclusions
  • Mostly seen in immature granulocytes
  • Found in blast cells associated with acute myeloid leukemia
 

Hairy Cell

  • 10-20 microns
  • Round, oval  or kidney-shaped nucleus
  • Pale grey-blue cytoplasm
  • Irregular fine “hairy” cytoplasmic projections